Towards compliant small-diameter vascular grafts: predictive analytical model and experiments

Bouchet, Mélusine, Gauthier, Matthieu, Maire, Marion, Ajji, Abdellah et Lerouge, Sophie. 2019. « Towards compliant small-diameter vascular grafts: predictive analytical model and experiments ». Materials Science and Engineering C, vol. 100. pp. 715-723.
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Résumé

The search for novel, more compliant vascular grafts for the replacement of blood vessels is ongoing, and predictive tools are needed to identify the most promising biomaterials. A simple analytical model was designed that enables the calculation of the ratio between the ultimate stress (σult) and the elastic modulus (E). To reach both the compliance of small-diameter coronary arteries (0.0725%/mmHg) and a burst pressure of 2031 mmHg, a material with a minimum σult/E ratio of 1.78 is required. Based on this result and on data from the literature, random electrospun Polyurethane/Polycaprolactone (PU/PCL) tubular scaffolds were fabricated and compared to commercial ePTFE prostheses. PU/PCL grafts showed mechanical properties close to those of native arteries, with a circumferential elastic modulus of 4.8 MPa and a compliance of 0.036%/mmHg at physiological pressure range (80–120 mmHg) for a 145 μm-thick prosthesis. In contrast, commercial expanded polytetrafluoroethylene (ePTFE) grafts presented a high Young's modulus (17.4 MPa) and poor compliance of 0.0034%/mmHg. The electrospun PU/PCL did not however reach the target values as its σult/E ratio was lower than expected, at 1.54, well below the calculated threshold (1.78). The model tended to overestimate both the compliance and burst pressure, with the differences between the analytical and experimental results ranging between 13 and 34%, depending on the pressure range tested. This can be explained by the anisotropy of random electrospun PU/PCL and its slightly non-linear elastic behavior, in contrast to the hypotheses of our model. Impermeability tests showed that the electrospun scaffolds were impermeable to blood for all thicknesses above 50 μm. In conclusion, this analytical model allows to select materials with suitable mechanical properties for the design of small-diameter vascular grafts. The novel electrospun PU/PCL tubular scaffolds showed strongly improved compliance as compared to commercial ePTFE prostheses.

Type de document:	Article publié dans une revue, révisé par les pairs
Professeur:	Professeur Lerouge, Sophie
Affiliation:	Génie mécanique
Date de dépôt:	05 avr. 2019 20:09
Dernière modification:	21 oct. 2022 16:39
URI:	https://espace2.etsmtl.ca/id/eprint/18496

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