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Comparative evaluation of artificial neural networks and data analysis in predicting liposome size in a periodic disturbance micromixer

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Ocampo, Ixchel, López, Rubén R., Camacho-León, Sergio, Nerguizian, Vahé and Stiharu, Ion. 2021. « Comparative evaluation of artificial neural networks and data analysis in predicting liposome size in a periodic disturbance micromixer ». Micromachines, vol. 12, nº 10.
Compte des citations dans Scopus : 7.

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Abstract

Artificial neural networks (ANN) and data analysis (DA) are powerful tools for supporting decision-making. They are employed in diverse fields, and one of them is nanotechnology; for example, in predicting silver nanoparticles size. To our knowledge, we are the first to use ANN to predict liposome size (LZ). Liposomes are lipid nanoparticles used in different biomedical applications that can be produced in Dean-Forces-based microdevices such as the Periodic Disturbance Micromixer (PDM). In this work, ANN and DA techniques are used to build a LZ prediction model by using the most relevant variables in a PDM, the Flow Rate Radio (FRR), and the Total Flow Rate (TFR), and the temperature, solvents, and concentrations were kept constant. The ANN was designed in MATLAB and fed data from 60 experiments with 70% training, 15% validation, and 15% testing. For DA, a regression analysis was used. The model was evaluated; it showed a 0.98147 correlation coefficient for training and 0.97247 in total data compared with 0.882 obtained by DA.

Item Type: Peer reviewed article published in a journal
Professor:
Professor
Nerguizian, Vahé
Affiliation: Génie électrique
Date Deposited: 26 Oct 2021 20:14
Last Modified: 16 Oct 2023 18:21
URI: https://espace2.etsmtl.ca/id/eprint/23447

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