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Sleep stage transitions and sleep-dependent memory consolidation in children with narcolepsy–cataplexy

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Gagnon, Katia, Rey, Amandine E., Guignard-Perret, Anne, Guyon, Aurore, Reynaud, Eve, Herbillon, Vania, Lina, Jean-Marc, Carrier, Julie, Franco, Patricia and Mazza, Stéphanie. 2023. « Sleep stage transitions and sleep-dependent memory consolidation in children with narcolepsy–cataplexy ». Children, vol. 10, nº 10.

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Abstract

Electroencephalographic sleep stage transitions and altered first REM sleep period transitions have been identified as biomarkers of type 1 narcolepsy in adults, but not in children. Studies on memory complaints in narcolepsy have not yet investigated sleep-dependent memory consolidation. We aimed to explore stage transitions; more specifically altered REM sleep transition and its relationship with sleep-dependent memory consolidation in children with narcolepsy. Twenty-one children with narcolepsy–cataplexy and twenty-three healthy control children completed overnight polysomnography and sleep-dependent memory consolidation tests. Overnight transition rates (number of transitions per hour), global relative transition frequencies (number of transitions between a stage and all other stages/total number of transitions � 100), overnight transitions to REM sleep (transition from a given stage to REM/total REM transitions � 100), and altered first REM sleep period transitions (transitions from wake or N1 to the first REM period) were computed. Narcoleptic children had a significantly higher overnight transition rate with a higher global relative transition frequencies to wake. A lower sleep-dependent memory consolidation score found in children with narcolepsy was associated with a higher overnight transition frequency. As observed in narcoleptic adults, 90.48% of narcoleptic children exhibited an altered first REM sleep transition. As in adults, the altered sleep stage transition is also present in children with narcolepsy–cataplexy, and a higher transition rate could have an impact on sleep-dependent memory consolidation. These potential biomarkers could help diagnose type 1 narcolepsy in children more quickly; however, further studies with larger cohorts, including of those with type 2 narcolepsy and hypersomnia, are needed.

Item Type: Peer reviewed article published in a journal
Professor:
Professor
Lina, Jean-Marc
Affiliation: Génie électrique
Date Deposited: 16 Nov 2023 15:51
Last Modified: 18 Dec 2023 16:04
URI: https://espace2.etsmtl.ca/id/eprint/28011

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