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Clinical evaluation of in-house-produced 3D-printed nasopharyngeal swabs for covid-19 testing

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Lapierre, Simon Grandjean, Bedwani, Stéphane, Deblois, François, Fortin, Audray, Cuervo, Natalia Zamorano, Zerouali, Karim, Caron, Elise, Morency-Potvin, Philippe, Gagnon, Simon, Nguissan, Nakome, Arlotto, Pascale, Hardy, Isabelle, Boutin, Catherine-Audrey, Tremblay, Cécile, Coutlée, François, de Guise, Jacques et Grandvaux, Nathalie. 2021. « Clinical evaluation of in-house-produced 3D-printed nasopharyngeal swabs for covid-19 testing ». Viruses, vol. 13, nº 9.
Compte des citations dans Scopus : 4.

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Résumé

3D-printed alternatives to standard flocked swabs were rapidly developed to provide a response to the unprecedented and sudden need for an exponentially growing amount of diagnostic tools to fight the COVID-19 pandemic. In light of the anticipated shortage, a hospital-based 3Dprinting platform was implemented in our institution for the production of swabs for nasopharyngeal and oropharyngeal sampling based on the freely available, open-source design provided to the community by University of South Florida’s Health Radiology and Northwell Health System teams as a replacement for locally used commercial swabs. Validation of our 3D-printed swabs was performed with a head-to-head diagnostic accuracy study of the 3D-printed “Northwell model” with the cobas PCR Media® swab sample kit. We observed an excellent concordance (total agreement 96.8%, Kappa 0.936) in results obtained with the 3D-printed and flocked swabs, indicating that the in-house 3D-printed swab could be used reliably in the context of a shortage of flocked swabs. To our knowledge, this is the first study to report on autonomous hospital-based production and clinical validation of 3D-printed swabs.

Type de document: Article publié dans une revue, révisé par les pairs
Professeur:
Professeur
de Guise, Jacques A.
Affiliation: Génie des systèmes
Date de dépôt: 22 sept. 2021 20:26
Dernière modification: 16 oct. 2023 18:29
URI: https://espace2.etsmtl.ca/id/eprint/23182

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