Biomechanical markers associations with pain, symptoms, and disability compared to radiographic severity in knee osteoarthritis patients: A secondary analysis from a cluster randomized controlled trial

Bensalma, Fatima, Hagemeister, Nicola, Cagnin, Alix, Ouakrim, Youssef, Bureau, Nathalie J., Choiniere, Manon et Mezghani, Neila. 2022. « Biomechanical markers associations with pain, symptoms, and disability compared to radiographic severity in knee osteoarthritis patients: A secondary analysis from a cluster randomized controlled trial ». BMC Musculoskeletal Disorders, vol. 23, nº 1.
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Résumé

Background: Conventional radiography is commonly used to diagnose knee osteoarthritis (OA), but also to guide clinical decision-making, despite a well-established discordance between radiographic severity and patient symp- toms. The incidence and progression of OA is driven, in part, by biomechanical markers. Therefore, these dynamic markers may be a good metric of functional status and actionable targets for clinicians when developing conservative treatment plans. The aim of this study was to assess the associations between biomechanical markers and self- reported knee function compared to radiographic severity. Methods: This was a secondary analysis of data from a randomized controlled trial (RCT) conducted in primary care clinics with knee OA participants. Correlation coefficients (canonical (ρ) and structural (Corr)) were assessed between the Knee Injury and Osteoarthritis Outcome Score (KOOS) and both, radiographic OA severity using the Kellgren- Lawrence grade, and three-dimensional biomechanical markers quantified by a knee kinesiography exam. Significant differences between coefficients were assessed using Fischer’s z-transformation method to compare correlations from dependent samples. Results: KOOS and biomechanical data were significantly more associated than KOOS and X-ray grading (ρ: 0.41 vs 0.20; p < 0.001). Structural correlation (Corr) between KOOS and X-ray grade was 0.202 (4% of variance explained), while individual biomechanical markers, such as the flexion during loading, explained up to 14% of KOOS variance (i.e., Corr2). Biomechanical markers showed the strongest associations with Pain and Activity of Daily Living KOOS subscales (both > 36% variance explained), while X-ray grading was most associated with Symptoms subscale (21% explained; all p ≤ 0.001). Conclusions: Knee biomechanical markers are associated with patient-reported knee function to a greater extent than X-ray grading, but both provide complementary information in the assessment of OA patients. Understanding

Type de document:	Article publié dans une revue, révisé par les pairs
Professeur:	Professeur Hagemeister, Nicola
Affiliation:	Génie des systèmes
Date de dépôt:	02 nov. 2022 19:12
Dernière modification:	15 nov. 2022 14:08
URI:	https://espace2.etsmtl.ca/id/eprint/25695

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