Posttraumatic stress and traumatic brain injury: Cognition, behavior, and neuroimaging markers in Vietnam veterans

Marcolini, Sofia, Rojczyk, Philine, Seitz-Holland, Johanna, Koerte, Inga K., Alosco, Michael L. et Bouix, Sylvain. 2023. « Posttraumatic stress and traumatic brain injury: Cognition, behavior, and neuroimaging markers in Vietnam veterans ». Journal of Alzheimer's Disease, vol. 95, nº 4. pp. 1427-1448.

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Résumé

Background: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are common in Veterans and linked to behavioral disturbances, increased risk of cognitive decline, and Alzheimer’s disease. Objective: We studied the synergistic effects of PTSD and TBI on behavioral, cognitive, and neuroimaging measures in Vietnam war Veterans. Methods: Data were acquired at baseline and after about one-year from male Veterans categorized into: PTSD, TBI, PTSD+TBI, andVeteran controls without PTSD or TBI.We applied manual tractography to examine white matter microstructure of three fiber tracts: uncinate fasciculus (N= 91), cingulum (N= 87), and inferior longitudinal fasciculus (N= 95). ANCOVAs were used to compareVeterans’ baseline behavioral and cognitive functioning (N= 285), white matter microstructure, amyloid-� (N= 230), and tau PET (N= 120). Additional ANCOVAs examined scores’ differences from baseline to follow-up.

Type de document:	Article publié dans une revue, révisé par les pairs
Professeur:	Professeur Bouix, Sylvain
Affiliation:	Génie logiciel et des technologies de l'information
Date de dépôt:	16 nov. 2023 15:52
Dernière modification:	31 janv. 2024 20:15
URI:	https://espace2.etsmtl.ca/id/eprint/28016

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