Ward, H. B., Beermann, A., Xie, J., Yildiz, G., Felix, K. M., Addington, J., Bearden, C. E., Cadenhead, K., Cannon, T. D., Cornblatt, B., Keshavan, M., Mathalon, D., Perkins, D. O., Seidman, L., Stone, W. S., Tsuang, M. T., Walker, E. F., Woods, S., Coleman, M. J., Bouix, S., Holt, D. J., Öngür, D., Breier, A., Shenton, M. E., Heckers, S., Halko, M. A., Lewandowski, K. E. et Brady, R. O..
2024.
« Robust brain correlates of cognitive performance in psychosis and its prodrome ».
Biological Psychiatry.
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Résumé
BACKGROUND: Neurocognitive impairment is a well-known phenomenon in schizophrenia that begins prior to psychosis onset. Connectome-wide association studies have inconsistently linked cognitive performance to resting-state functional magnetic resonance imaging. We hypothesized that a carefully selected cognitive instrument and refined population would allow identification of reliable brain-behavior associations with connectome-wide association studies. To test this hypothesis, we first identified brain-cognition correlations via a connectome-wide association study in early psychosis. We then asked, in an independent dataset, if these braincognition relationships would generalize to individuals who develop psychosis in the future. METHODS: The Seidman Auditory Continuous Performance Task (ACPT) effectively differentiates healthy participants from those with psychosis. Our connectome-wide association study used the HCP-EP (Human Connectome Project for Early Psychosis) (n = 183) to identify links between connectivity and ACPT performance. We then analyzed data from the NAPLS2 (North American Prodrome Longitudinal Study 2) (n = 345), a multisite prospective study of individuals at risk for psychosis. We tested the connectome-wide association study–identified cognition-connectivity relationship in both individuals at risk for psychosis and control participants. RESULTS: Our connectome-wide association study in early-course psychosis identified robust associations between better ACPT performance and higher prefrontal-somatomotor connectivity (p , .005). Prefrontal-somatomotor connectivity was also related to ACPT performance in at-risk individuals who would develop psychosis (n = 17). This finding was not observed in nonconverters (n = 196) or control participants (n = 132). CONCLUSIONS: This connectome-wide association study identified reproducible links between connectivity and cognition in separate samples of individuals with psychosis and at-risk individuals who would later develop psychosis. A carefully selected task and population improves the ability of connectome-wide association studies to identify reliable brain-phenotype relationships.
| Type de document: | Article publié dans une revue, révisé par les pairs |
|---|---|
| Professeur: | Professeur Bouix, Sylvain |
| Affiliation: | Génie logiciel et des technologies de l'information |
| Date de dépôt: | 20 sept. 2024 18:19 |
| Dernière modification: | 28 oct. 2024 15:53 |
| URI: | https://espace2.etsmtl.ca/id/eprint/29553 |
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