de Carvalho Arjona, Jéssica, Samara, Mazen, Ulsen, Carina, Valenzuela Diaz, Francisco Rolando et Demarquette, Nicole Raymonde.
2025.
« Isoniazid adsorption and release by Cloisite and Laponite: An effect of surface charge ».
Materials Chemistry and Physics, vol. 344.
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Résumé
Two different smectites, Cloisite (CL), a montmorillonite, and Laponite (LP), a synthetic hectorite-like clay, were investigated for their efficiency in isoniazid (INH) adsorption and release mechanisms. Adsorption was conducted at an acidic pH = 2 to leverage the protonation effect of INH. At acidic pH, the clays exhibited different surface charges: −12 mV for CL and −2 mV for LP, indicating a stronger negative charge on CL. These changes affected the INH incorporation and release, increasing the attachment on the clay surface. CL, the clay with the lowest surface charge, manifested a higher incorporation of INH, 115 mg/g, and a more controlled release of INH in the stomach environment (less than 8 %, against 25 % for LP). These values compared favorably with those cited in the literature and demonstrated a potential for drug delivery. Although X-ray diffraction (XRD) did not show an increase in the basal distance for either clay, Fourier-transform infrared spectroscopy (FTIR) and thermogravimetry analysis (TGA) showed the interaction between clay and drug after the incorporation. Compared to literature, the hybrids developed in this study exhibited higher drug loading and a more effective pH-responsive release, particularly at pH 2. This is especially important for oral drug delivery, where protecting the drug in the stomach and enabling its release in the intestine can enhance bioavailability. These findings underscore the potential of smectite clays as promising candidates for INH-controlled release and contribute to identifying key-clay characteristics for effective oral drug delivery systems.
| Type de document: | Article publié dans une revue, révisé par les pairs |
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| Professeur: | Professeur Demarquette, Nicole R. |
| Affiliation: | Génie mécanique |
| Date de dépôt: | 02 juin 2025 18:30 |
| Dernière modification: | 04 juin 2025 17:52 |
| URI: | https://espace2.etsmtl.ca/id/eprint/30973 |
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