Seitz-Holland, J., Haaf, M., Mendes-Silva, A. P., Penzel, N., Berberich, C., Breithaupt, L., Leicht, G., Bouix, S., Coleman, M. J., Kotler, E., Kim, N., Lewandowski, K. E., Holt, D., Keshavan, M. S., Öngür, D., Breier, A., Shenton, M. E., Diniz, B. S., Arnold, S. E. et Kubicki, M..
2025.
« Inflammation and aging in psychosis - a transdiagnostic proteomics study using the human connectome project for early psychosis (HCP-EP) ».
[Résumé d'une communication à une conférence]. International Journal of Neuropsychopharmacology, vol. 28, nº suppl. 2.
ii179-ii180.
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Résumé
Since protein expression plays a key role in mediating genetic risk, the field of proteomics—the in-depth analysis of proteins—has gained renewed importance in neuropsychiatric research. Recent technical advancements now allow for the simultaneous examination of multiple proteins, revealing complex pathological processes in mental illnesses. Various studies have demonstrated that proteomics can elucidate underlying molecular mechanisms, identify clinically relevant biomarkers, and suggest novel treatment strategies, particularly in neurodegenerative disorders. Although its application in psychiatry remains less explored, proteins have proven to be promising transdiagnostic markers for understanding disease heterogeneity. In psychosis, proteomic studies support the “inflamm-aging” hypothesis, wherein chronic low-grade inflammation accelerates biological aging and contributes to disease onset and progression. These insights underscore the importance of integrating protein-based approaches to detect inflammatory subtypes.
| Type de document: | Article publié dans une revue, révisé par les pairs |
|---|---|
| Informations complémentaires: | Thématique : 36th CINP World Congress Neuropsychopharmacology - CINP-AsCNP 2025 Joint Congress 15-18 June 2025 Congress Abstracts (Melbourne, Australia) |
| Professeur: | Professeur Bouix, Sylvain |
| Affiliation: | Génie logiciel et des technologies de l'information |
| Date de dépôt: | 04 sept. 2025 12:57 |
| Dernière modification: | 24 sept. 2025 23:05 |
| URI: | https://espace2.etsmtl.ca/id/eprint/31639 |
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