Forouzanfar, Mohamad, Sardooeinasab, Sepehr, Baker, Fiona C., Colrain, Ian M. et de Zambotti, Massimiliano.
2025.
« Tone-evoked sleep electroencephalographic slow oscillations as a function of peripheral rhythms: New insights into the brain–heart integration ».
Journal of Sleep Research.
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Résumé
Recent studies have shown that acoustic stimulation, a common neuromodulation technique, can enhance slow-wave activity SWA), which is associated with immune, autonomic nervous system activity and cognitive health benefits. Despite some disa- greement, many studies suggest that maximising tone-evoked SWA depends on the timing of the acoustic stimulus in relation to ongoing cortical slow oscillations. Given the close connection between the central and peripheral systems during sleep, par- ticularly at the cortico–cardiac level, we here aimed to examine the overlooked relationship between the timing of stimulation and the dominant cortical and cardiac rhythms. We evaluated the effect of acoustic stimulation in different phases of the EEG slow oscillation SO; ~0.8 Hz) component of SWA 0.5–4 Hz) and heart rate HR) low-frequency LF) 0.04–0.15 Hz) and high- frequency HF) 0.15–0.4 Hz) oscillations on tone-evoked EEG slow activity and HR profiles. One hundred thirty-three adoles- cents underwent overnight polysomnography where acoustic tones 80 dB at 1000 Hz for 50 msec) were played with a random 15–30 s interstimulus interval. The analysis was limited to artefact and arousal-free episodes of NREM sleep. Playing acoustic tones in the upstate phases of EEG SOs, upstate phases of HR LF oscillations and downstate phases of HR HF oscillations induced significantly higher peak-to-peak amplitude EEG SOs 110%, 16% and 7%, respectively) p < 0.001) and HR oscillations 16%, 56% and 25%, respectively) p < 0.001), produced a greater number of EEG SOs 22%, 12% and 5%, respectively) and increased the SWA 3%, 14% and 3%, respectively) p < 0.05) in contrast to playing tones in the other phase downstate phases of EEG SOs, downstate phases of LF oscillations and upstate phases of HR HF oscillations). Our findings reveal complex interactions between the cen- tral and peripheral nervous systems in processing external stimuli, leading to significant variations in postcortical and cardiac oscillations. These results have potential implications for developing deep sleep enhancement technologies using adaptive inter- ventions based on multidimensional oscillations.
| Type de document: | Article publié dans une revue, révisé par les pairs |
|---|---|
| Professeur: | Professeur Forouzanfar, Mohamad |
| Affiliation: | Génie des systèmes |
| Date de dépôt: | 23 oct. 2025 13:58 |
| Dernière modification: | 14 nov. 2025 20:21 |
| URI: | https://espace2.etsmtl.ca/id/eprint/32586 |
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