Savoji, Houman, Hadjizadeh, Afra, Maire, Marion, Ajji, Abdellah, Wertheimer, Michael R. et Lerouge, Sophie.
2014.
« Electrospun nanofiber scaffolds and plasma polymerization: A promising combination towards complete, stable endothelial lining for vascular grafts ».
Macromolecular Bioscience, vol. 14, nº 8.
pp. 1084-1095.
Compte des citations dans Scopus : 48.
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Lerouge S 2014 7808 Electrospun nanofiber scaffolds and plasma.pdf - Version acceptée Licence d'utilisation : Tous les droits réservés aux détenteurs du droit d'auteur. Télécharger (1MB) | Prévisualisation |
Résumé
In the quest to reduce risk of thrombosis in vascular grafts, it is essential to provide a surface with morphological and mechanical properties close to those of the extracellular matrix beneath the luminal endothelium, and to favor the growth of a confluent, stable monolayer of endothelial cells. This is accomplished here by combining electrospun poly(ethylene terephthalate) (PET) mats with an amine‐rich thin plasma‐polymerized coating, designated “L‐PPE:N.” Its deposition does not modify the open, highly porous mats and leads only to small changes in mechanical properties. L‐PPE:N significantly improves the adhesion and growth of human umbilical vein endothelial cells (HUVEC) and their resistance to flow‐induced shear stress. These properties favor the formation of desired confluent HUVEC monolayers on the topmost surface, unlike conventional vascular grafts (ePTFE or woven PET), where cells migrate inside the material. This combination is therefore highly advantageous for the pre‐endothelialization of the luminal side of small‐diameter vascular prostheses.
| Type de document: | Article publié dans une revue, révisé par les pairs |
|---|---|
| Professeur: | Professeur Lerouge, Sophie |
| Affiliation: | Génie mécanique |
| Date de dépôt: | 22 mai 2014 13:34 |
| Dernière modification: | 22 oct. 2018 13:58 |
| URI: | https://espace2.etsmtl.ca/id/eprint/7808 |
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