Lequoy, Pauline, Liberelle, Benoît, De Crescenzo, Gregory et Lerouge, Sophie.
2014.
« Additive benefits of chondroitin sulfate and oriented tethered epidermal growth factor for vascular smooth muscle cell survival ».
Macromolecular Bioscience, vol. 14, nº 5.
pp. 720-730.
Compte des citations dans Scopus : 15.
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Résumé
An anti‐apoptotic coating combining chondroitin sulfate (CS) and coiled–coil‐based tethering of epidermal growth factor (EGF) is designed for vascular applications. The oriented tethering strategy enables to reach higher EGF surface densities compared to the commonly used random covalent grafting, while using much lower concentrations of EGF during incubation. It also significantly improves vascular smooth muscle cell (VSMC) survival and resistance to apoptosis in serum‐free conditions. The comparison of CS and low‐fouling carboxymethylated dextran as a sublayer for growth factors highlights the tremendous benefit of CS thanks to its selective protein resistance and good cell adhesion properties. This approach can be tuned by capturing other growth factors on CS through coiled–coil interactions.
| Type de document: | Article publié dans une revue, révisé par les pairs |
|---|---|
| Professeur: | Professeur Lerouge, Sophie |
| Affiliation: | Génie mécanique |
| Date de dépôt: | 22 mai 2014 13:35 |
| Dernière modification: | 18 oct. 2018 16:59 |
| URI: | https://espace2.etsmtl.ca/id/eprint/7811 |
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