Additive benefits of chondroitin sulfate and oriented tethered epidermal growth factor for vascular smooth muscle cell survival

Lequoy, Pauline, Liberelle, Benoît, De Crescenzo, Gregory and Lerouge, Sophie. 2014. « Additive benefits of chondroitin sulfate and oriented tethered epidermal growth factor for vascular smooth muscle cell survival ». Macromolecular Bioscience, vol. 14, nº 5. pp. 720-730.
Compte des citations dans Scopus : 15.

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Abstract

An anti‐apoptotic coating combining chondroitin sulfate (CS) and coiled–coil‐based tethering of epidermal growth factor (EGF) is designed for vascular applications. The oriented tethering strategy enables to reach higher EGF surface densities compared to the commonly used random covalent grafting, while using much lower concentrations of EGF during incubation. It also significantly improves vascular smooth muscle cell (VSMC) survival and resistance to apoptosis in serum‐free conditions. The comparison of CS and low‐fouling carboxymethylated dextran as a sublayer for growth factors highlights the tremendous benefit of CS thanks to its selective protein resistance and good cell adhesion properties. This approach can be tuned by capturing other growth factors on CS through coiled–coil interactions.

Item Type:	Peer reviewed article published in a journal
Professor:	Professor Lerouge, Sophie
Affiliation:	Génie mécanique
Date Deposited:	22 May 2014 13:35
Last Modified:	18 Oct 2018 16:59
URI:	https://espace2.etsmtl.ca/id/eprint/7811

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