Drai, Jeffrey et Czekanski, Aleksander.
2025.
« Exploring challenges and solutions in hydrogel failure and fracture mechanics for advancing vascular tissue engineering ».
In Proceedings of the CSME-CFDSC-CSR 2025 International Congress (Montreal, QC, Canada, May 25-28, 2025)
Coll. « Progress in Canadian Mechanical Engineering », vol. 8.
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Résumé
Vascular tissue engineering requires the creation of new materials that mimic the biomechanical and biofunctional properties of native tissues. Reinforced natural hydrogels are good candidates due to their biocompatibility, tunable mechanical properties, and support of cellular activities. Their application in vascular constructs is, nevertheless, hindered by inadequate information on their fracture and failure mechanisms under physiological conditions. This review introduces a comprehensive assessment of hydrogel fracture mechanics involving mechanical properties, toughness, and factors affecting failure, like crosslinking density, porosity, and swelling stress. It provides a comparison among various theoretical tools, including linear and nonlinear fracture mechanics, theories of poroelasticity, and finite element analysis, as predictive tools for hydrogel. In addition to this, the review highlights how multiscale modeling plays a major role in transitioning from molecular-level interactions to macroscopic properties. Through the integration of theoretical models and empirical findings, this study reveals the shortcomings of existing methodologies and suggests directions for future research. The final objective of developing a better understanding of fracture and failure mechanisms is to enable the development of strong hydrogel-based materials for vascular tissue engineering.
| Type de document: | Compte rendu de conférence |
|---|---|
| Éditeurs: | Éditeurs ORCID Hof, Lucas A. NON SPÉCIFIÉ Di Labbio, Giuseppe NON SPÉCIFIÉ Tahan, Antoine NON SPÉCIFIÉ Sanjosé, Marlène NON SPÉCIFIÉ Lalonde, Sébastien NON SPÉCIFIÉ Demarquette, Nicole R. NON SPÉCIFIÉ |
| Date de dépôt: | 18 déc. 2025 15:09 |
| Dernière modification: | 18 déc. 2025 15:09 |
| URI: | https://espace2.etsmtl.ca/id/eprint/32388 |
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